The Slaughter-House Six was formed because Ambuscade wished for some lackeys to help him in his fights against heroes. He went to Revo-Corp, supplier of his powers and his gear, and they also supplied him with the members Re-Volt, Magman, Ray Manta, and Desert Eagle. They were eventually defeated, though Ambuscade cloaked and escaped before they were arrested.
After they were released, they eventually got back together. Glamour attempted to take control of them, but they did not like that. So, using her powers of illusion and various tech, she created an illusion of Ambuscade. They followed him through other fights.
Come Tactics, they have mostly dispersed. In the RPG, Glamour leads a new version of the Slaughter-House Six.
- First seen in the Challenges document, as a comic book cover
- The Slaughter-House Six are likely an homage to the original lineup of Marvel's Sinister Six villain team, which was composed of villains from the Spider-Man comics: Doctor Octopus (Ray Manta), Kraven the Hunter (Ambuscade), Mysterio (Glamour), Vulture (Desert Eagle), Sandman (Magman), and Electro (Re-Volt).